Bipolar Disorder & Comorbid Type II Diabetes: Ramifications Of Unstable Insulin Levels

Paul J. Flaer, Mustafa Z. Younis

Abstract


The human body literally “runs” on glucose. Blood Insulin levels were the primary hormonal players in regulating concentrations of both extra- and intracellular glucose in the maintenance of somatic homeostasis and metabolism. As to the broad actions of glucose, most body systems were involved with this small, polar compound in some way including nutritionally, physiologically, osmotically (osmolarity), and metabolically. Furthermore, acting over all neurological pathways, glucose was the absolute required form of nutrition for nerve cells. It follows that fluctuations of glucose concentrations both inside and outside each cell had a considerable impact on behavior. The symptoms and genetics of Type II Diabetes and Bipolar Disorder were intermingled multidimensionally—congruent with the effects of almost tidal concentrations of glucose. The comorbid relationship of Type II Diabetes and Bipolar Disorder has been studied epidemiologically by researchers and clinicians. The interplay of the comorbid conditions of Bipolar Disorder and Type II Diabetes could be applied to patients in both the diagnostic and therapeutic phases of treatment. It is recommended in this work that all patients that were diagnosed with Bipolar Disorder have a complete medical workup to diagnose common conditions—especially the comorbid presence of Type II Diabetes.

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References


Centers for Disease Control and Prevention (CDC). National diabetes fact sheet. Atlanta, GA: U.S. Department of Health and Human Services; 2011.

Heyda RJ. Highest Rates of Bipolar Disorder in the United States: Why? Health Matters. Psychol Today. New York: Sussex Publishers, LLC; 2012.

Flaer P, Younis M. Community Interventions in Bipolar Disorder – When the system fails. APCJ. 2011;7(1):1-8.

Goldbaum E. Mental illness linked to diabetes. University of Buffalo (UB) Reporter 2003; Updated 2012.

Nussey S, Whitehead NS. Endocrinology: An integrated approach. Oxford: BIOS Scientific Publishers; 2001.

Dickerson SS, Kemeny ME. Acute stressors and cortisol responses: A theoretical integration and synthesis of

laboratory research. Psychol Bull 2004;130(3):355-391.

Hirschowitz J, Kolevzon A, Garakani A. The pharmacological treatment of bipolar disorder: The question of

5) Fiedorowicz JG, Palagummi NM, Forman-Hoffman VL, Miller DD, Haynes WG. Elevated prevalence of obesity, metabolic syndrome, and cardiovascular risk factors in bipolar disorder. Ann Clin Psychiatry 2008;20(3):131- 137.

modern advances. Harv Rev Psychiatry. 2010;18(5):266-278.

National Institute for Health and Clinical Excellence (NICE). Understanding NICE guidance: Bipolar disorder. NHS reference # N1077; 2006.

McIntire RS, Mancini DA, Pearce MM, Silverstone P, Chue P, et al. Mood and psychotic disorders and Type 2 Diabetes” A metabolic triad. Can J Diabetes.

;29(2):122-132.

McIntire RS, Alsuwaidan M, Goldstein BI, Taylor VH, Shaffer A, et al. The Canadian

network for mood and anxiety treatments (CANMAT) task force recommendations for

the management of patients with mood disorders and comorbid metabolic disorders. Psychiatry.2012;24(1):69-81.

Ann Clin

Sjohölm A, Welsh N, & Hellerström C. Lithium increases DNA replication, polyamine content, and insulin

secretion by rat pancreatic beta-cells. Am J Physiol 1992;262 (2 Pt 1):C391-395.

Stern MP, Williams K, Gonzalez-Villalpando C, Hunt KJ, Haffner SM. Does the metabolic syndrome improve identification of individuals at risk of Type 2 Diabetes and/or cardiovascular disease? Diabetes Care, 2004;27:2676-2681.

Freeman S. Special report on Diabetes and Bipolar Disorder; 2010. Website: www.bipolar-lives.com.


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